Delivery Technologies for Biopharmaceuticals: Peptides, by Lene Jorgensen, Hanne Morck Nielson

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By Lene Jorgensen, Hanne Morck Nielson

Advances in biotechnology have supplied scientists with more and more biopharmaceuticals corresponding to novel peptide and protein medicinal drugs in addition to nucleic acid established medicines for gene remedy. in spite of the fact that, profitable supply of those biopharmaceuticals is an immense problem simply because their molecular houses result in negative actual and chemical balance within the physique and restricted membrane permeability. accordingly researchers are constructing a variety of new supply applied sciences and fabrics to permit those new medicinal drugs to be brought intact to their objective websites.

Delivery applied sciences for Biopharmaceuticals describes techniques to beat the most obstacles for profitable supply of healing peptides, proteins, and nucleic acid-based medicinal drugs or vaccines regarding the location of management and the objective web site. a few of the methods defined are mentioned in formulations in present medical trials in addition to in advertised items. Contents contain:

  • challenges in supply of biopharmaceuticals
  • novel formula ways for peptide and protein injectables
  • non-viral chemical vectors and viral expertise for supply of nucleic acid established medicinal drugs
  • immune reaction, adjuvants and supply platforms for vaccines
  • several examples of supply platforms for different biopharmaceuticals
  • a severe overview of supply applied sciences for biopharmaceuticals 

Delivery applied sciences for Biopharmaceuticals is a necessary single-volume creation to the applied sciences utilized by researchers to make sure effective supply of this interesting new classification of substances. will probably be of price to researchers and scholars operating in drug supply, formula, biopharmaceuticals, medicinal chemistry, and new fabrics development.Content:
Chapter 1 demanding situations in supply of Biopharmaceuticals; the necessity for complicated supply platforms (pages 1–8): Hanne Morck Nielsen and Lene Jorgensen
Chapter 2 Novel formula methods for Peptide and Protein Injectables (pages 9–28): Mingshi Yang and Sven Frokjaer
Chapter three Novel Non?Injectable formula methods of Peptides and Proteins (pages 29–67): Shirui Mao, Dongmei Cun and Yoshiaki Kawashima
Chapter four Chemical Vectors for supply of Nucleic Acid?Based medications (pages 69–92): Elizabeth A. Vasievich and Leaf Huang
Chapter five Viral know-how for supply of Nucleic Acids (pages 93–112): Shervin Bahrami and Finn Skou Pedersen
Chapter 6 The Innate Immune Responses, Adjuvants and supply platforms (pages 113–127): S. Moein Moghimi
Chapter 7 Lipid Nanoparticle?Based platforms for supply of Biomacromolecule Therapeutics (pages 129–148): Susana Martins, Domingos C. Ferreira and Eliana B. Souto
Chapter eight Dendrimers in supply of Biopharmaceuticals (pages 149–168): Chandan Thomas and Fakhrul Ahsan
Chapter nine amendment of Peptides and Proteins (pages 169–191): Susanne Hostrup, Kasper Huus and Henrik Parshad
Chapter 10 Nanocarriers for the supply of Peptides and Proteins (pages 193–205): Kenneth Lundstrom
Chapter eleven Polymer?Based supply platforms for Oral supply of Peptides and Proteins (pages 207–226): Bruno Sarmento, Domingos Ferreira and Teofilo Vasconcelos
Chapter 12 complicated Pulmonary supply of Peptides or Proteins utilizing Polymeric debris (pages 227–244): Yu Seok Youn, Kang Choon Lee, You Han Bae, Kun Na and Eun Seong Lee
Chapter thirteen Polymer Microparticles for Nucleic Acid supply (pages 245–267): Tim Pearce, Jared Hierman and Chun Wang
Chapter 14 Pulmonary supply of Small Interfering RNA for Novel Therapeutics (pages 269–289): Qing Ge, David Evans, John J. Xu, Harry H. Yang and Patrick Y. Lu
Chapter 15 Lipid?Based Formulations for siRNA supply (pages 291–304): Camilla Foged, Pieter Vader and Raymond M. Schiffelers
Chapter sixteen mobile Bioavailability of Peptide Nucleic Acids (PNAs) Conjugated to mobilephone Penetrating Peptides (pages 305–338): Takehiko Shiraishi and Peter E. Nielsen
Chapter 17 DEAE?dextran?MMA Graft Copolymer for Non?Viral supply of DNA (pages 339–355): Yasuhiko Onishi, Yuki Eshita and Masaaki Mizuno
Chapter 18 Liposomes in Adjuvant structures for Parenteral supply of Vaccines (pages 357–376): Dennis Christensen, Karen Korsholm, Grith Kroyer wooden, Afzal Mohammed, Vincent Bramwell, Peter Andersen, Else Marie Agger and Yvonne Perrie
Chapter 19 Influenza Virosomes as supply platforms for Antigens (pages 377–393): Mario Amacker, Stefan Moese, Andreas R. Kammer, Ari Helenius and Rinaldo Zurbriggen
Chapter 20 GRAZAX®: An Oromucosal Vaccine for Treating Grass Pollen hypersensitive reaction with Immunotherapy (pages 395–404): Annette Rommelmayer Lundegaard, Lise Lund and Jorgen Nedergaard Larsen
Chapter 21 supply applied sciences for Biopharmaceuticals: A severe evaluation (pages 405–412): Marco van de Weert

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Extra info for Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines

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Et al. (1999) The use of aqueous PEG/ dextran phase separation for the preparation of dextran microspheres. Int. J. , 183, 29–32. 87. L. M. (2008) Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms. J. Pharm. , 97, 2395–2404. 88. F. J. (1993) Development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation. Crit. Rev. Ther. , 10, 307–377. 89. , Stevenson, M. et al. (2000) DepToam™ technology: a vehicle for controlled delivery of protein and peptide drugs.

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Et al. (2004) Micropipette manipulation – a technique to evaluate the stability of water-in-oil emulsions containing proteins. J. Pharm. , 93, 2994–3003. 3. Caliceti, P. M. (2003) Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates. Adv. Drug Del. , 55, 1261–1277. 4. , Lobell, J. D. (1991) Chondroosseous dysplasia in severe combined immunodeficiency due to adenosine deaminase deficiency (chondroosseous dysplasia in ADA deficiency SCID). Pediatr. , 21, 447–448.

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