CXCR4 by Moser B.

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1997) Survey of cancer genetics. Cancer, 80(3), 523–32 2. , et al. (1996) Statement of the American Society of Clinical Oncology: Genetic testing for cancer susceptibility. J Clin Oncol, 14, 1730–6 3. Y. A. (1996) Uncertainties and challenges: communicating risk in the context of familial cancer. A report to the National Cancer Institute of Canada. School of Nursing, University of British Columbia. Giles CAUSES OF CANCER Of the 9–10 million new cancers diagnosed around the globe each year, 53% could be prevented given our current knowledge.

The most radiosensitive phases are M and G2, and the most radioresistant is the S phase. A daily dose will selectively kill sensitive cells leaving a partly synchronized cell population. The next day, some of the cells that survived in the radioresistant phases will have progressed to radiosensitive phases. This self-sensitizing effect of cell cycle redistribution occurs in both tumours and early responding normal tissues. 38 THE PRINCIPLES OF CANCER TREATMENT Geographical Miss Achieving the aim of clonal eradication by radiation also depends on physical factors.

Australia is notable for its high incidence of skin cancer with over 1,000 per 100,000 person years in 1995. A significant, but unknown, proportion is attributable to occupational exposure to ultraviolet radiation. Other Causes Whilst, tobacco, diet, viruses, and ultraviolet light are major causes of cancer, it is estimated that approximately 5% of cancers in the developed world are due to occupational exposures. Over 300 chemicals have now been confirmed as carcinogens by the International Agency for Research on Cancer.

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