By Delia C. Baquiran
By Waldemar Priebe
content material: Unresolved structure-activity relationships in anthracycline analogue improvement / Edward M. Acton --
Non-cross-resistant anthracyclines with diminished basicity and elevated balance of the glycosidic bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-He Ling, and Roman Perez-Soler --
Fluorinated anthracyclinones and their glycosylated items / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, and Federico Arcamone --
Semisynthetic rhodomycins and anthracycline prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, and Hans-Harold Sedlacek --
artificial concepts for reversal of anthracycline resistance and cardiotoxicity / Claude Monneret, Jean-Claude Florent, Jean-Pierre Gesson, Jean-Claude Jacquesy, François Tillequin, and Michel Koch --
Synthesis and organic actions of fluorinated daunorubicin and doxorubicin analogues / Tsutomu Tsuchiya and Yasushi Takagi --
Redox chemistry of anthracyclines and use of oxomorpholinyl radicals / Tad H. Koch and Giorgio Gaudiano --
Synthesis of anthraquinone analogues of associated anthracycline / Ping Ge and Richard A. Russell --
Synthesis and research of structure-activity relationships of recent periods of anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, and Maria Grandi --
Molecular attractiveness of DNA through daunorubicin / Jonathan B. Chaires --
Adducts of DNA and anthracycline antibiotics : constructions, interactions, and actions / Jasmine Y.-T. Wang, Mark Chao, and Andrew H.-J. Wang --
DNA topoisomerases and their inhibition via anthracyclines / Yves Pommier --
Anthracycline antihelicase motion : new mechanism with implications for guanosine-cytidine intercalation specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, and Linda Malkas --
Membrane biophysical parameters influencing anthracycline motion / Ratna Mehta and Thomas G. Burke --
sign transduction platforms in doxorubicin hydrochloride mechanism of motion / Paul Vichi, James music, Jean Hess, and Thomas R. Tritton --
research of multidrug transporter in dwelling cells : program to uptake and liberate of anthracycline derivatives by way of drug-resistant K562 cells / Arlette Garnier-Suillerot, Frédéric Frézard, Marie-Nicole Borrel, Elene Pereira, Jolanta Tarasiuk, and Marina Fiallo --
position of reactive-oxygen metabolism in cardiac toxicity of anthracycline antibiotics / James H. Doroshow --
Amelioration of anthracycline-induced cardiotoxicity by means of natural chemical compounds / Donald T. Witiak and Eugene H. Herman --
Use of drug companies to ameliorate the healing index of anthracycline antibiotics / Roman Perez-Soler, Steven Sugarman, Yiyu Zou, and Waldemar Priebe.
By Bruce C. Baguley (Author), David J. Kerr (Author)
The following in one resource is a whole spectrum of rules at the improvement of latest anticancer medicinal drugs. Containing concise studies of multidisciplinary fields of study, this ebook bargains a wealth of principles on present and destiny molecular pursuits for drug layout, together with sign transduction, the telephone department cycle, and programmed mobile dying. distinct descriptions of resources for brand new medicinal drugs and strategies for checking out and medical trial layout also are supplied. KEY FEATURES:* One paintings that may be consulted for all elements of anticancer drug improvement* Concise studies of analysis fields, mixed with functional medical element, written through across the world revered specialists* A wealth of rules on present and destiny molecular objectives for drug layout, together with sign transduction, the cellphone department cycle, and programmed telephone demise * specific descriptions of the assets of recent anticancer medicines, together with combinatorial chemistry, phage show, and typical items* dialogue of the way new medicinal drugs could be established in preclinical platforms, together with the most recent expertise of robot assay platforms, cellphone tradition, and experimental animal concepts* 1000's of references that let the reader to entry suitable medical and clinical literature* transparent illustrations, a few in colour, that offer either realizing of the sphere and fabric for educating
By Robert B. Livingston, Stephen K. Carter (auth.)
The scientific trials application of anti-tumor medicinal drugs was once all started via the nationwide melanoma Institute in 1955. long ago 15 years, this nationwide community has accrued a wide physique of information on the entire famous anti-tumor medicines in addition to upon new, experimentally promising brokers. whereas crucial of those reviews were released, there has remained a wealth of knowledge now not quite often on hand to the medical neighborhood. Drs. Carter and Livingston haven't in basic terms succeeded in organ~z~ng this huge corpus, they've got furthermore analyzed and interpreted the scientific information in a manner that would be hugely invaluable for future years. From a perusal of this quantity it turns into obvious that a few medicines are extra energetic opposed to definite tumors than were discovered; that the facts for the task of sure medications opposed to particular tumors is usually tenuous; unusually, that a few hugely lively brokers have by no means been attempted opposed to a number of the quite universal tumors. Their huge paintings has supplied not just entry to the not easy information, it has additionally proven the necessity for examine to fill in vital gaps in our wisdom. The authors and the IFI/Plenum Press are to be congratulated for this beneficial and demanding paintings. C. Gordon Zubrod, M. D. medical Director for Chemotherapy nationwide melanoma Institute nationwide Institutes of wellbeing and fitness Bethesda, Maryland v Acknowledgment The authors desire to thank Dr. C. Gordon Zubrod and Dr.
By Michael D. Stubblefield MD;Michael W. O'Dell MD
Authored via many of the world's top melanoma specialists from broad ranging disciplines together with oncology, radiation oncology, neurosurgery, orthopedic surgical procedure, and radiology this compact quantity presents authoritative state of the art primer point overviews of a few of the melanoma forms, their evaluate, and therapy. each element of oncology is roofed with transparent, updated descriptions of the final rules and ideas primary to reaching a medical appreciation of the rules of melanoma care.
Each bankruptcy is concise yet highlights the fundamental tenets overall healthiness care execs operating with melanoma sufferers want to know to appreciate the illnesses and present treatments. To facilitate assessment, Key Points are boxed in each one bankruptcy to summarize very important scientific info and ideas at a look. This e-book represents a synthesis of knowledge from a few of the most sensible physicians in oncology that's not as simply accessed at any place else.
Features of Synopsis of medical Oncology include:
- Multi-specialty specialist authorship
- Focus on therapeutics administration of cancer
- Key issues boxed in every one bankruptcy for fast evaluation
By Robert Cheng, Lisa A. Ridnour, Sharon A. Glynn, Christopher H. Switzer (auth.), Benjamin Bonavida (eds.)
The Nobel Prize in body structure and drugs used to be presented in 1998 to medical professionals Furchgott, Ignarro, and Murad for his or her discoveries touching on "Nitric oxide (NO) as a signaling molecule within the cardiovascular system." NO-inducing phone signaling occasions in the mobilephone generating it and the diffusibility to NO in different cells have resulted in the invention of many different physiological features in lots of kinds of cells together with melanoma. Noteworthy, nitroglycerin that has been used for the remedy of chest soreness and linked cardiovascular ailments is at present being investigated for its healing impact in scientific reports in sufferers with melanoma. additional, a number of NO donor compounds have proven, in preclinical experiences, anti-tumoral chemopreventive and healing activities.
"Nitric Oxide and melanoma: analysis, Prevention and Therapy", edited by way of Benjamin Bonavida, Ph.D., stories a number of novel purposes of NO in melanoma, a brand new box that has quickly received credibility and knowing on the biochemical and molecular degrees. many of the chapters during this complete quantity (25 contributions), written via famous specialists within the box, convey up to date our present figuring out and potential destiny medical purposes of NO.
By Gillian M. Murphy (auth.), Gregor B. E. Jemec, Lajos Kemeny, Donald Miech (eds.)
Books mark the growth of guy when you consider that they have been invented. via them we will achieve perception into the minds of our predecessors larger than via the other medium. They describe how the fragile interaction among perform and excellent, that is greater often called evolution, has introduced ahead the societies during which we now dwell. A ebook marks the synthesis of data another way from person papers. a undeniable adulthood and quantity of figuring out and data is important prior to the cloth is appropriate for a e-book. The timing of the cognitive and analytical synt- sis represented through a booklet is accordingly the most important; too quickly and it truly is misplaced in hypothesis, too past due and it's outdated information. Non-melanoma pores and skin melanoma is usual; it reasons morbidity, it reasons a burden on society, and remedy has been generally nearly solely surgical. a long time of scientific technological know-how have despite the fact that now introduced ahead a few ideas that can support either the prognosis and remedy of epidermis melanoma with out bodily removal it, both by myself or together in remedy courses adapted to the person patients.