Cancer du testicule by Alain Houlgatte

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By Alain Houlgatte

Le melanoma du testicule a bénéficié d'importantes avancées thérapeutiques transformant radicalement son pronostic. Cet ouvrage aborde les différents progrès innovations tant dans le domaine du diagnostic - avec l'apport de l'imagerie moderne et de l'anatomopathologie - que thérapeutique. l. a. position de l. a. chimiothérapie de même que celle de l. a. chirurgie sont largement détaillées, plaçant ainsi l'urologue au cœur de l'équipe pluridisciplinaire prenant en cost ces sufferers.

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NG CS, Husband JE, Padhani AT et al. (1997) Evaluation by magnetic resonance imaging of the inferior vena cava in patients with non seminomatous germ cell tumors of the testis metastatic to the retroperitoneum. Br J Urol 79: 942-51 18. Corral DA, Varma DG, Jackson EF et al. (2000) Magnetic resonance imaging and magnetic resonance angiography before postchemotherapy retroperitoneal lymph node dissection. Urology 55: 262-6 19. Donohue JP, Rowland RG, Kopecky K et al. (1987) Correlation of computerized tomographic changes and histological finding in 80 patients having radical retroperitoneal lymph node dissection after chemotherapy for testis cancer.

Ainsi, à l’inverse de hst-1, c-kit est exprimé dans 80 % des séminomes et 7 % des tumeurs non séminomateuses. L’expression de c-kit peut être réduite ou disparaître durant la transformation en tumeur non séminomateuse. Le gène de la cycline D2 (CCND2 localisé en 12p13) pourrait être le meilleur candidat pour la carcinogenèse précoce. La cycline D2 agit par formation de complexes avec les cdk/cdk6 et intervient dans la phosphorylation de la protéine Rb, ce qui stimule la prolifération cellulaire au point de contrôle G1/S par libération des facteurs de transcription quand Rb est phosphorylée.

Formes familiales et héréditaires associées à des mutations rares Fréquence et caractéristiques des formes familiales La fréquence des formes familiales (familles présentant au moins deux cas de cancers du testicule) varie selon les études de 1,2 à 3,5 %. Les formes familiales ont certaines caractéristiques différentes des cancers sporadiques : l’âge au diagnostic est significativement plus jeune dans les formes familiales que sporadiques : 29 ans versus 32,5 ans dans une étude qui portait sur 42 familles avec au moins deux cas de cancers.

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