Cancer diagnostics : current and future trends by Robert M Nakamura; et al

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By Robert M Nakamura; et al

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Current research reveals the importance of the silencing of suppressor gene by promoter methylation on tumors. DNMT1/DNMT3b encoded methyltransferase is a key molecule responsible for the methylation of suppressor genes (43). RERb2, retinoic acid receptor gene silenced by methylation (48), which causes acute promyelocytic leukemia (APL) or acute myeloid leukemia (AML), has been confirmed in experimental models. In addition, cases of colon, lung, lym-phoma,, and breast cancer with a high percentage of methylation have been reported.

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Gynecol. Scand. 80(6): 583–585. 24. Tampellini M, Berruti A, Gorzegno G, et al. 2001. Independent factors predict supranormal CA 15-3 serum levels in advanced breast cancer patients at first disease relapse. Tumour Biol. 22(6):367–373. 25. Ychou M, Duffour J, Kramar A, Gourgou S, Grenier J. 2000. Clinical significance and prognostic value of CA72-4 compared with CEA and CA19-9 in patients with gastric cancer. Dis. Markers. 16(3–4):105–110. 26. Yamamoto T, Ito K, Ohi M, et al. 2001. Diagnostic significance of digtal rectal examination and transrectal ultrasonography in men with prostate-specific antigen levels of 4 ng/mL or less.

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