Breast Cancer: An Atlas of Investigation and Management by Matthew D. Barber;Jeremy St. J. Thomas;J. Michael Dixon

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By Matthew D. Barber;Jeremy St. J. Thomas;J. Michael Dixon

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Extra info for Breast Cancer: An Atlas of Investigation and Management (Atlases of Investigation and Management)

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Both are large genes with functions related to DNA repair and various mutations result in malignancy. Molecular screening for abnormalities in individuals at risk can be cumbersome and the situation has been complicated by the fact that both genes have been patented. A mutation of BRCA1 gene confers a lifetime risk of breast cancer of around 75% in addition to an increased risk of ovarian, prostate, and colon cancer. Disease onset is typically at a relatively early age. Mutation of the BRCA2 gene results in a lifetime risk of breast cancer of around 60%, again with disease onset at a relatively early age.

J Natl Cancer Inst 99:272–82. Kriege M, et al. (2004). Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351:427–37. Moss SM, et al. (2006). Effect of mammographic screening from age 40 years on breast cancer mortality at 10 years’ follow-up: a randomised controlled trial. Lanc e t 368:2053–60. Nystrom L, e t al. (2002). Long-term effects of mammography screening: updated overview of the Swedish randomised trials. Lancet 359:909–19.

2006]. 10) A number of conditions occur in the breast which are not cancers but which exhibit a range of behaviour with some malignant characteristics. Phyllodes tumours usually present clinically as a large (>3 cm), well-defined, mobile lump. Histologically, they consist of epithelial and connective tissue components and differentiation from the much more common, innocent fibroadenoma can be difficult both clinically, on imaging, and even on histology. They are more common in older women (mean age 40–50 years).

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