Biological Response Modifiers in Human Oncology and by Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven

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By Yuichi Yamamura, Ichiro Azuma (auth.), Thomas Klein, Steven Specter, Herman Friedman, Andor Szentivanyi (eds.)

The subject of organic reaction modifiers has attracted the eye of many biomedical investigators, together with immunologists, oncologists, pharmacologists, microbiologists, and biochemists, in addition to medical practitioners of drugs. This has happened frequently as a result of the awareness that the advanced approach of mobile and humoral interactions culminating in a effective immune reaction is lower than beautiful regulatory regulate for regular immune responses and that lack of keep an eye on may possibly markedly impression the aptitude of a bunch to reply in a effective demeanour to the various immunologic "insults" encountered within the surroundings. moreover, organic reaction amendment is taken into account through many to be a normal offshoot of the rather new software of "immunotherapy" to melanoma. it really is widely known that "immunotherapy" used to be practiced on the finish of the final century and the start of this century while it was once well-known that microbial infections have been brought on by unique species of micro organism and that passive management of serum con­ taining antibody to those microbes or their items may possibly, in lots of situations, favorably impact the end result of an infectious process.

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Geczy and A. L. de Weck. 1976. Antibodies to guinea pig 1ymphokines. J. Immuno1. 117: 66-72 • 3. , E. S. Martin, K. Webb, D. Weldon, N. o. Hill, J. Duvall and J. M. Hill. 1982. Regression of malignant melanoma in a dog by local injections of a partially purified preparation containing human a-lymphotoxin. Proc. Soc. Exp. Biol. Med. 169: 291-294. MONOCLONAL ANTIBODIES AS ANTICANCER AGENTS Robert K. Oldham National Cancer Institute, Division of Cancer Treatment Biological Response Modifiers Program, Frederick Cancer Research Center, Frederick, MD (USA) INTRODUCTION A major problem with current modalities of cancer treatment has been the lack of specificity of the treatment for the cancer cell.

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