Antibody-Mediated Drug Delivery Systems: Concepts, by Yashwant Pathak, Simon Benita

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By Yashwant Pathak, Simon Benita

Content material:
Chapter 1 Antibody?Mediated Drug supply platforms: common evaluate and purposes (pages 1–12): Navdeep Kaur, Karthikeyan Subramani and Yashwant Pathak
Chapter 2 Immunoliposomes for Cardiovascular concentrating on (pages 13–33): Tatyana Levchenko, William Hartner and Vladimir P. Torchilin
Chapter three Antibody?Mediated Drug supply platforms for Breast melanoma Therapeutics (pages 35–55): Leonor Munoz Alcivar and Yashwant Pathak
Chapter four improvement of Immunonconjugates for in Vivo supply: melanoma prognosis, Imaging, and treatment (pages 57–81): Arutselvan Natarajan
Chapter five Mathematical versions of Anti?TNF treatments and their Correlation with Tuberculosis (pages 83–104): Simeone Marino, Mohammad Fallahi?Sichani, Jennifer J. Linderman and Denise E. Kirschner
Chapter 6 specific Nanoparticles in Radiotherapy (pages 105–128): Misty Muscarella and Yashwant Pathak
Chapter 7 Electrically?Enhanced supply of substances and Conjugates for melanoma therapy (pages 129–143): Arutselvan Natarajan, Luca Campana and Raji Sundararajan
Chapter eight Characterization of Monoclonal Antibody variations and Glycosylation (pages 145–167): Ting Zheng, Srinivasa Rao, Jeff Rohrer and Chris Pohl
Chapter nine Antibody?Mediated Drug supply process for Lymphatic concentrating on remedy (pages 169–190): Fang Wu, Hong Ding and Zhirong Zhang
Chapter 10 equipment for Nanoparticle Conjugation to Monoclonal Antibodies (pages 191–207): Junling Li and Chin ok. Ng
Chapter eleven Single?Use structures in Animal Cell–Based Bioproduction (pages 209–228): William G. Whitford
Chapter 12 Immunoliposomes for particular Drug supply (pages 229–266): Manuela Calin
Chapter thirteen Gene treatment focusing on Kidney illnesses: Routes and autos (pages 267–277): Yoshitaka Isaka, Yoshitsugu Takabatake and Hiromi Rakugi
Chapter 14 Detection of Antibodies to Poly(Ethylene Glycol) Polymers utilizing Double?Antigen?Bridging Immunogenicity ELISA (pages 279–290): Yijuan Liu, Helen Reidler, Jing Pan, David Milunic, Dujie Qin, Dave Chen, Yli Remo Vallejo and Ray Yin
Chapter 15 Antibodies in Nanomedicine and Microimaging tools (pages 291–349): Rakesh Sharma
Chapter sixteen equipment for Polymeric Nanoparticle Conjugation to Monoclonal Antibodies (pages 351–363): Uyen Minh Le, Hieu Tran and Yashwant Pathak
Chapter 17 Plant?Derived Antibodies for tutorial, business, and healing purposes (pages 365–381): Slavko Komarnytsky and Nikolai Borisjuk
Chapter 18 Monoclonal Antibodies as Biopharmaceuticals (pages 383–389): Girish J. Kotwal
Chapter 19 Pulmonary concentrating on of Nanoparticles and Monoclonal Antibodies (pages 391–405): Weiyuan Chang
Chapter 20 Antibody?Mediated Arthritis and New healing Avenues (pages 407–426): Kutty Selva Nandakumar
Chapter 21 Immunonanoparticles for Nuclear Imaging and Radiotherapy (pages 427–456): Oren Giladi and Simon Benita
Chapter 22 Monoclonal Antibodies within the therapy of bronchial asthma (pages 457–472): Glenn J. Whelan

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Expert Rev. Anticancer Ther. 7, 11–17. 19. , Muller-Hermelink, H. , Marx, A. (2010). A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model. J. Biomed. Biotechnol . 2010:187621. Epub Feb. 24, 2010. 20. , Stump, B. (2010). Antibody–drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug. , 21(1); 5–13. 21. Alley, S. , Okeley, N. , Senter, P. D. (2010). Antibody–drug conjugates: targeted drug delivery for cancer.

These targeted immunoliposomes would then bind selectively to damaged cells and fuse with or plug the damaged membranes. The validity of this idea was shown with hypoxic myocytes in vitro [30] and in an in vivo model of cardiac ischemia [31,32]. Although antithrombus monoclonal antibodies seem to be very convenient vectors for the targeted delivery of thrombolytics, attempts have been made to use other targeting moieties. A number of additional blood proteins and peptides demonstrated increased accumulation in the thrombus.

This process renders the cells highly specific for a single antigenic sequence. During maturation, each B cell undergoes selection mechanisms which ensure that it is not only specific for one antigen, but also that it does not recognize self-antigen. During this process, any B cells that recognize self-antigen either die or their activity is permanently suppressed. When a B cell has gone through the entire recombination process, it becomes fully mature. Once fully matured, the cell is at a stage where it 4 CHAPTER 1 ANTIBODY-MEDIATED DRUG DELIVERY SYSTEMS will activate only when it recognizes a particular amino acid sequence during the course of a pathogenic infection.

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